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Alam P, Huang W, Adam M, Nieman M, Stutenroth S, Tranter M, Wang Y, Kanisicak O. MCM2 mediates post-MI cardioprotection by promoting the pro-angiogenic cardiosome signaling. bioRxiv. 2024 December. doi: https://doi.org/10.1101/2024.12.12.628232.

Alam P, Tharp DL, Bowles HJ, Grisanti LA, Bui H, Bender SB, Bowles DK. Genetic silencing of KCa3.1 inhibits atherosclerosis in ApoE null mice. bioRxiv. 2024 December. doi: https://doi.org/10.1101/2024.12.11.628017.

McNamara JW, Song T, Alam P, Binek A, Singh RR, Nieman ML, Koch SE, Ivey MJ, Lynch TL, Rubinstein J, Jin JP, Lorenz JN, Van Eyk JE, Kanisicak O, Sadayappan S. Fast skeletal myosin binding protein-C expression exacerbates dysfunction in heart failure. bioRxiv. 2024 May 3;. doi: 10.1101/2024.04.30.591979. PubMed PMID: 38746225; PubMed Central PMCID: PMC11092637

Slone S, Anthony SR, Green LC, Nieman ML, Alam P, Wu X, Roy S, Aube J, Xu L, Lorenz JN, Owens AP, Kanisicak O, Tranter M. HuR inhibition reduces post-ischemic cardiac remodeling by dampening acute inflammatory gene expression and the innate immune response. bioRxiv. 2023 Jan 18;. doi: 10.1101/2023.01.17.524420. PubMed PMID: 36711986; PubMed Central PMCID: PMC9882229.

Alam P, Maliken BD, Jones SM, Ivey MJ, Wu Z, Wang Y, Kanisicak O. Cardiac Remodeling and Repair: Recent Approaches, Advancements, and Future Perspective. Int J Mol Sci. 2021 Dec 3;22(23). doi: 10.3390/ijms222313104. Review. PubMed PMID: 34884909; PubMed Central PMCID: PMC8658114.

Sharma K, Mishra A, Singh HN, Parashar D, Alam P, Thinlas T, Mohammad G, Kukreti R, Syed MA, Pasha MAQ. High-altitude pulmonary edema is aggravated by risk loci and associated transcription factors in HIF-prolyl hydroxylases. Hum Mol Genet. 2021 Aug 28;30(18):1734-1749. doi: 10.1093/hmg/ddab139. PubMed PMID: 34007987

Guarnieri AR, Anthony SR, Gozdiff A, Green LC, Fleifil SM, Slone S, Nieman ML, Alam P, Benoit JB, Owens AP, Kanisicak O, Tranter M. Adipocyte-specific deletion of HuR induces spontaneous cardiac hypertrophy and fibrosis. Am J Physiol Heart Circ Physiol. 2021 Jul 1;321(1):H228-H241. doi: 10.1152/ajpheart.00957.2020. Epub 2021 May 21. PubMed PMID: 34018851; PubMed Central PMCID: PMC8321812.

Arif M, Alam P, Ahmed RP, Pandey R, Faridi HM, Sadayappan S. Upregulated Angiogenesis Is Incompetent to Rescue Dilated Cardiomyopathy Phenotype in Mice. Cells. 2021 Mar 31;10(4). doi: 10.3390/cells10040771. PubMed PMID: 33807406; PubMed Central PMCID: PMC8066105.

Kharbanda C, Alam MS, Hamid H, Ali Y, Nazreen S, Dhulap A, Alam P, Pasha MAQ. In silico designing, in vitro and in vivo evaluation of potential PPAR-γ agonists derived from aryl propionic acid scaffold. Bioorg Chem. 2021 Jan;106:104458. doi: 10.1016/j.bioorg.2020.104458. Epub 2020 Nov 6. PubMed PMID: 33234295

Alam P, Amlal S, Thakar CV, Amlal H. Acetazolamide causes renal [Formula: see text] wasting but inhibits ammoniagenesis and prevents the correction of metabolic acidosis by the kidney. Am J Physiol Renal Physiol. 2020 Sep 1;319(3):F366-F379. doi: 10.1152/ajprenal.00501.2019. Epub 2020 Jul 13. PubMed PMID: 32657159; PubMed Central PMCID: PMC7509283

Alam P, Agarwal G, Kumar R, Mishra A, Saini N, Mohammad G, Pasha MAQ. Susceptibility to high-altitude pulmonary edema is associated with circulating miRNA levels under hypobaric hypoxia conditions. Am J Physiol Lung Cell Mol Physiol. 2020 Aug 1;319(2):L360-L368. doi: 10.1152/ajplung.00168.2020. Epub 2020 Jun 17. PubMed PMID: 32692577

Alam P, Haile B, Arif M, Pandey R, Rokvic M, Nieman M, Maliken BD, Paul A, Wang YG, Sadayappan S, Ahmed RPH, Kanisicak O. Inhibition of Senescence-Associated Genes Rb1 and Meis2 in Adult Cardiomyocytes Results in Cell Cycle Reentry and Cardiac Repair Post-Myocardial Infarction. J Am Heart Assoc. 2019 Aug 6;8(15):e012089. doi: 10.1161/JAHA.119.012089. Epub 2019 Jul 18. PubMed PMID: 31315484; PubMed Central PMCID: PMC6761626

Chakravarti AR, Pacelli S, Alam P, Bagchi S, Modaresi S, Czirok A, Ahmed RPH, Paul A. Pre-Conditioning Stem Cells in a Biomimetic Environment for Enhanced Cardiac Tissue Repair: In Vitro and In Vivo Analysis. Cell Mol Bioeng. 2018 Oct;11(5):321-336. doi: 10.1007/s12195-018-0543-x. Epub 2018 Jul 26. PubMed PMID: 31579283; PubMed Central PMCID: PMC6774647

Waters R, Alam P, Pacelli S, Chakravarti AR, Ahmed RPH, Paul A. Stem cell-inspired secretome-rich injectable hydrogel to repair injured cardiac tissue. Acta Biomater. 2018 Mar 15;69:95-106. doi: 10.1016/j.actbio.2017.12.025. Epub 2017 Dec 24. PubMed PMID: 29281806; PubMed Central PMCID: PMC5831493.

Arif M, Pandey R, Alam P, Jiang S, Sadayappan S, Paul A, Ahmed RPH. MicroRNA-210-mediated proliferation, survival, and angiogenesis promote cardiac repair post myocardial infarction in rodents. J Mol Med (Berl). 2017 Dec;95(12):1369-1385. doi: 10.1007/s00109-017-1591-8. Epub 2017 Sep 25. PubMed PMID: 28948298; PubMed Central PMCID: PMC5941944

Kharbanda C, Alam MS, Hamid H, Javed K, Bano S, Ali Y, Dhulap A, Alam P, Pasha MA. Novel Piperine Derivatives with Antidiabetic Effect as PPAR-γ Agonists. Chem Biol Drug Des. 2016 Sep;88(3):354-62. doi: 10.1111/cbdd.12760. Epub 2016 May 27. PubMed PMID: 27037532.

Nazreen S, Alam MS, Hamid H, Shahar Yar M, Dhulap A, Alam P, Pasha MA, Bano S, Alam MM, Haider S, Kharbanda C, Ali Y, Pillai K. Design, Synthesis, and Biological Evaluation of Thiazolidine-2,4-dione Conjugates as PPAR-γ Agonists. Arch Pharm (Weinheim). 2015 Jun;348(6):421-32. doi: 10.1002/ardp.201400280. Epub 2015 Apr 21. PubMed PMID: 25900064

Kumar R, Kohli S, Mishra A, Garg R, Alam P, Stobdan T, Nejatizadeh A, Gupta M, Tyagi S, Pasha MA. Interactions between the genes of vasodilatation pathways influence blood pressure and nitric oxide level in hypertension. Am J Hypertens. 2015 Feb;28(2):239-47. doi: 10.1093/ajh/hpu130. Epub 2014 Aug 26. PubMed PMID: 25159081

Nazreen S, Alam MS, Hamid H, Yar MS, Shafi S, Dhulap A, Alam P, Pasha MA, Bano S, Alam MM, Haider S, Ali Y, Kharbanda C, Pillai KK. Design, synthesis, in silico molecular docking and biological evaluation of novel oxadiazole based thiazolidine-2,4-diones bis-heterocycles as PPAR-γ agonists. Eur J Med Chem. 2014 Nov 24;87:175-85. doi: 10.1016/j.ejmech.2014.09.010. Epub 2014 Sep 16. PubMed PMID: 25255433.

Kharbanda C, Alam MS, Hamid H, Javed K, Shafi S, Ali Y, Alam P, Pasha MA, Dhulap A, Bano S, Nazreen S, Haider S. Novel benzenesulfonylureas containing thiophenylpyrazoline moiety as potential antidiabetic and anticancer agents. Bioorg Med Chem Lett. 2014 Nov 15;24(22):5298-303. doi: 10.1016/j.bmcl.2014.09.044. Epub 2014 Sep 23. PubMed PMID: 25442322.

Nazreen S, Alam MS, Hamid H, Yar MS, Dhulap A, Alam P, Pasha MA, Bano S, Alam MM, Haider S, Kharbanda C, Ali Y, Pillai KK. Thiazolidine-2,4-diones derivatives as PPAR-γ agonists: synthesis, molecular docking, in vitro and in vivo antidiabetic activity with hepatotoxicity risk evaluation and effect on PPAR-γ gene expression. Bioorg Med Chem Lett. 2014 Jul 15;24(14):3034-42. doi: 10.1016/j.bmcl.2014.05.034. Epub 2014 May 22. PubMed PMID: 24890090.

Haider S, Alam MS, Hamid H, Shafi S, Dhulap A, Hussain F, Alam P, Umar S, Pasha MA, Bano S, Nazreen S, Ali Y, Kharbanda C. Synthesis of novel 2-mercaptobenzoxazole based 1,2,3-triazoles as inhibitors of proinflammatory cytokines and suppressors of COX-2 gene expression. Eur J Med Chem. 2014 Jun 23;81:204-17. doi: 10.1016/j.ejmech.2014.05.012. Epub 2014 May 4. PubMed PMID: 24836072.

Kumar R, Kohli S, Alam P, Barkotoky R, Gupta M, Tyagi S, Jain SK, Pasha MA. Interactions between the FTO and GNB3 genes contribute to varied clinical phenotypes in hypertension. PLoS One. 2013;8(5):e63934. doi: 10.1371/journal.pone.0063934. Print 2013. PubMed PMID: 23691120; PubMed Central PMCID: PMC3653800.

Ali Z, Mishra A, Kumar R, Alam P, Pandey P, Ram R, Thinlas T, Mohammad G, Pasha MA. Interactions among vascular-tone modulators contribute to high altitude pulmonary edema and augmented vasoreactivity in highlanders. PLoS One. 2012;7(9):e44049. doi: 10.1371/journal.pone.0044049. Epub 2012 Sep 11. PubMed PMID: 22984459; PubMed Central PMCID: PMC3439466.

Mishra A, Ali Z, Vibhuti A, Kumar R, Alam P, Ram R, Thinlas T, Mohammad G, Pasha MA. CYBA and GSTP1 variants associate with oxidative stress under hypobaric hypoxia as observed in high-altitude pulmonary oedema. Clin Sci (Lond). 2012 Mar;122(6):299-309. doi: 10.1042/CS20110205. PubMed PMID: 21973220

Arif E, Vibhuti A, Alam P, Deepak D, Singh B, Athar M, Pasha MA. Association of CYP2E1 and NAT2 gene polymorphisms with chronic obstructive pulmonary disease. Clin Chim Acta. 2007 Jul;382(1-2):37-42. doi: 10.1016/j.cca.2007.03.013. Epub 2007 Mar 24. PubMed PMID: 17442289.

Review

Alam P, Maliken BD, Jones SM, Ivey MJ, Wu Z, Wang Y, Kanisicak O. Cardiac Remodeling and Repair: Recent Approaches, Advancements, and Future Perspective. Int J Mol Sci. 2021 Dec 3;22(23). doi: 10.3390/ijms222313104. Review. PubMed PMID: 34884909; PubMed Central PMCID: PMC8658114.

Wu Z, Liang J, Huang W, Jiang L, Paul C, Gao X, Alam P, Kanisicak O, Xu M, Wang Y. Immunomodulatory effects of mesenchymal stem cells for the treatment of cardiac allograft rejection. Exp Biol Med (Maywood). 2021 Apr;246(7):851-860. doi: 10.1177/1535370220978650. Epub 2020 Dec 16. Review. PubMed PMID: 33327780; PubMed Central PMCID: PMC8719033

Alam P, Saini N, Pasha MA. MicroRNAs: An Apparent Switch for High-Altitude Pulmonary Edema. Microrna. 2015;4(3):158-67. doi: 10.2174/2211536604666151103121633. Review. PubMed PMID: 26527285.

Protocol

Alam P, Maliken BD, Ivey MJ, Jones SM, Kanisicak O. Isolation, Transfection, and Long-Term Culture of Adult Mouse and Rat Cardiomyocytes. J Vis Exp. 2020 Oct 10;(164). doi: 10.3791/61073. PubMed PMID: 33104067; PubMed Central PMCID: PMC8276663.

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